间羟胺对麻醉中血流动力学维持作用的系统评价

都丽萍,张钰宣,梅丹*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (7) : 613-617.

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PDF(1946 KB)
中国药学杂志 ›› 2014, Vol. 49 ›› Issue (7) : 613-617. DOI: 10.11669/cpj.2014.07.025
药物与临床

间羟胺对麻醉中血流动力学维持作用的系统评价

  • 都丽萍,张钰宣,梅丹*
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Effect of Metaraminol on Maintaining Hemodynamics during Anaesthesia:A Meta-Analysis

  • DU Li-ping, ZHANG Yu-xuan, MEI Dan*
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摘要

目的 评价间羟胺对麻醉中血流动力学的维持作用及安全性。方法 通过检索国内外常用医药数据库,纳入间羟胺对比常规/安慰剂或麻黄碱维持血循环的随机对照试验(RCT),并对随机对照试验进行方法学质量评价和Meta分析。结果 共纳入10个随机对照试验。间羟胺相比于常规/安慰剂组而言,维持麻醉中血流动力学的作用明显,两组麻醉中低血压发生率的差异有统计学意义;收缩压的降低幅度的差异有统计学意义;心率的变化幅度差异无统计学意义。间羟胺与麻黄碱相比,两组麻醉中低血压发生率的差异无明显的统计学意义;收缩压的降低幅度差异及心率的变化幅度的差异也均未显示出统计学意义;。结论 间羟胺能较好地维持麻醉期间的血流动力学,且疗效与麻黄碱相当;在安全性方面间羟胺不良反应发生率也比麻黄碱低。

Abstract

OBJECTIVE To evaluate the effectiveness and safety of metaraminol in maintaining hemodynamics during anaesthesia. METHODS Cochrane library, Pubmed, Embase, CBM, CNKI, VIP and Wanfang Database were searched. Randomized controlled trials(RCT) of metaraminol vs placebo or ephedrine in maintaining hemodynamics during anaesthesia were selected, and quality evaluation and Meta analysis were performed. RESULTS Ten RCTs were selected. The efficacy of metaraminol in maintaining hemodynamics during anaesthesia was better than placebo, it showed significant differences between the two groups in the incidence of hypotension and in the reduction of SAP , but no significant difference in the change of heart rate . There were no significant difference between metaraminol and ephedrine in the incidence of hypotension , the reduction of SAP and the change of heart rate . CONCLUSION The effect of metaraminol on maintaining hemodynamics during anaesthesia is equivalent to that of ephedrine; meanwhile metaraminol has fewer adverse effects than ephedrine.

关键词

间羟胺 / 麻醉 / 血流动力学

Key words

metaraminol / anaesthesia / hemodynamics

引用本文

导出引用
都丽萍,张钰宣,梅丹*. 间羟胺对麻醉中血流动力学维持作用的系统评价[J]. 中国药学杂志, 2014, 49(7): 613-617 https://doi.org/10.11669/cpj.2014.07.025
DU Li-ping, ZHANG Yu-xuan, MEI Dan*. Effect of Metaraminol on Maintaining Hemodynamics during Anaesthesia:A Meta-Analysis[J]. Chinese Pharmaceutical Journal, 2014, 49(7): 613-617 https://doi.org/10.11669/cpj.2014.07.025
中图分类号: R969.1   

参考文献

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基金

国家十一五科技支撑计划重点项目(2009BAI76B030215)
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